Macroplastique Clinical Data

Widely used for 25 years with excellent clinical results, Macroplastique is a closely studied product with more than 50 articles pertaining to its safety and effectiveness in treating stress urinary incontinence (SUI) in men and women as well as vesicoureteral reflux (VUR) in children.

Management of complications in use of urethral bulking agents in women for stress urinary incontinence – a meta-analysis
Islam, Majdee., Wadhwa, Harpreet., Dobbs, Ryan., and Kocjancic, Ervin. (2015). NOMCC: 214, PD28-04.
Initial retention after Macroplastique® injection as a predictor of success
Aggarwal, Himanshu., and Zimmern, Philippe. (2015). NOMCC: 206-207.
Prospective study of polydimethylsiloxane vs dextranomer/hyaluronic acid injection for treatment of vesicoureteral reflux.

Moore, K, Bolduc, S. (2014). J Urol, 192(6), 1794-800.
Vesico-ureteric reflux treatment by implant of polydimethylsiloxane (Macroplastique): Review of the literature. [Article in French]

Aubert, D. (2010) Prog Urol. 20(4):259.
Endoscopic treatment with polydimethylsiloxane in children with dilating vesico-ureteric reflux.

Bartoli, F., et al. (2006). BJU Int, 97(4), 805-808.
Comparison of different substances for subureteric injection in the management of vesicoureteric reflux in children.

Pelletier, A.K., et al. (2005). Can J Urol, 12(4), 2774-2777.
Polydimethylsiloxane injection versus open surgery for the treatment of vesicoureteral reflux in complete duplex systems.

Aboutaleb, H., et al. (2003). J Urol, 170(4 Pt 2), 1563-1565.
Subureteral polydimethylsiloxane injection versus extravesical reimplantation for primary low grade vesicoureteral reflux in children: A comparative study.

Aboutaleb, H., et al. (2003). J Urol, 169(1), 313-316.
Endoscopic treatment of vesicoureteric reflux (VUR) in children: Results of 9 years of use of Macroplastique (polydimethylsiloxane).

Kouamé, D.B., et al. (2003). Prog Urol, 13(6), 1368-1371.
Outcome of endoscopic treatment for vesicoureteral reflux in children using polydimethylsiloxane.

Al-Hunayan, A.A., et al. (2002). J Urol, 168(5), 2181-2183.
Prospective comparison and 1-year follow-up of a single endoscopic subureteral polydimethylsiloxane versus dextranomer/hyaluronic acid copolymer injection

Oswald, J., et al. (2002) Urology, 60(5), 894-897, discussion 898.
Uretero-vesical implantation after failure of endoscopic treatment of reflux: Anatomical and histological study of 61 resection specimens from 40 children.

Bertschy, C., et al. (2001). Prog Urol, 11(1), 113-117.
Efficacy of endoscopic subureteral polydimethylsiloxane injection for treatment of vesicoureteral reflux in children: A North American clinical report.

Herz, D., et al. (2001). J Urol, 166(5), 1880-1886.
Endoscopic treatment of vesicorenal reflux in children. Five-year assessment of the use of Macroplastique.

Dodat, H., et al. (1998). Prog Urol, 8(6), 1001-1006.
Subureteric polydimethylsiloxane injection in the treatment of vesico-ureteric reflux.

Ozyavuz, R., et al. (1998). Int Urol Nephrol, 30(2), 123-126.
Vesicoureteric reflux in children: Long-term results of endoscopic treatment by Macroplastique injection.

Dodat, H., et al. (2004). Prog Urol, 14(3), 380-384.
The long-term outcome of the endoscopic subureteric implantation of polydimethylsiloxane for treating vesico-ureteric reflux in children

van Capelle, et al (2004). BJU Int, 94(9),1348-1351.
Short and long term durability outcomes for female stress urinary incontinence: a systematic review and meta analysis of polydimethylsiloxane injection

Ghoniem, G., Miller, C. (2012). Poster, Society for Urodynamics and Female Urology (SUFU) annual meeting, New Orleans, LA.
Effect of the Macroplastique Implantation System for stress urinary incontinence in women with or without a history of an anti-incontinence operation.

Gumus I.I., Kaygusuz, I., Derbent, A., Simavli, S., & Kafali, H. (2011). International Urogynecological Journal, 22(6):743-749.
Effect of the Macroplastique Implantation System for stress urinary incontinence in women with or without a history of an anti-incontinence operation.

Gumus I.I., Kaygusuz, I., Derbent, A., Simavli, S., Kafali, H. (2011) International Urogynecological Journal, Online First 4/2/11
Cross-linked polydimethylsiloxane injection for female stress urinary incontinence: Results of a multicenter, randomized, controlled, single-blind study.

Ghoniem, G. et al. (2009). J Urol. 181, 204-210.
Review and analysis methodology of three pivotal urethral bulking agent trials: are the analyses treated equal?

Ghoniem, G. (2010). Poster, International Continence Society, Toronto, Canada.
Durability of Macroplastique® injection for female stress urinary incontinence: two years experience.

Corcos, J., et al. (2010). Poster, Society for Urodynamics and Female Urology, St. Petersburg, FL.
Urethral bulking agents used in the United States: how are they analyzed?

Ghoniem, G. et al. (2010). Poster, Society for Urodynamics and Female Urology, St. Petersburg, FL.
Improved outcomes in patients with transient urinary retention after Macroplastique urethral bulking procedure.

Williams, E. et al. (2010). Poster, Society for Urodynamics and Female Urology, St. Petersburg, FL.
Long term durability of polydimethylsiloxane injectable bulking agent (Macroplastique®) in urethral tissues: animal study histopathology.

Wustenberg, W. (2010). Poster, Society for Urodynamics and Female Urology, St. Petersburg, FL.
Redefining the success rate of bulking agents: Role of composite endpoints.

Renganathan, A., et al. (2009). Poster, International Continence Society, San Francisco, CA.
A cost effective approach to the mid-urethra: An economic analysis of the use of bulking agents and mid-urethral tapes.

Robinson, D., et al. (2009). Poster, International Urogynecological Association, Como, Italy.
Patient-perceived outcomes in the treatment of stress urinary incontinence: Focus on urethral injection therapy.

Chapple, C., et al. (2007). Int Urogynecol J Pelvic Floor Dysfunct, 18(2), 199-205.
Comparison between porcine dermal implant (Permacol) and silicone injection (Macroplastique) for urodynamic stress incontinence.

Bano, F., et al. (2005). Int Urogynecol J Pelvic Floor Dysfunct, 16(2), 147-150.
Injections trans-urétrales sous anesthésie locale en ambulatoire dans l’incontinence urinaire d’effort féminine: indications, faisabilité et resultants.

de Tayrac, R., et al (2005). J Gynecol Obstet Biol Reprod, 34 (cahier 1), 702–710.
Multicenter randomized controlled trial to evaluate Macroplastique urethral bulking agent for the treatment of female stress urinary incontinence.

Ghoniem, G., et al. (2005). Int Urogynec J, 16(Suppl2), S129-S130.
Pubovaginal sling versus transurethral Macroplastique for stress urinary incontinence and intrinsic sphincter deficiency: A prospective randomised controlled trial.

Maher, C.F., et al. (2005). BJOG, 112(6), 797-801.
Transurethral polydimethylsiloxane implantation: A valid option for the treatment of stress urinary incontinence due to intrinsic sphincter deficiency without urethral hypermobility.

Zullo, M.A., et al. (2005). J Urol, 173(3), 898-902.
Urethral Macroplastique injection as a treatment for female stress incontinence.

Sander, P., et al. (2004). Ugeskr Læger, 166, 3100-3102.
Treatment of intrinsic sphincter deficiency using the Macroplastique Implantation System: Two-year follow-up.

Tamanini, J.T., et al. (2004). J Endourol, 18(9), 906-911.
Macroplastique implantation system for the treatment of female stress urinary incontinence.

Tamanini, J.T., et al. (2003). J Urol, 169(6), 2229-2233.
Endoscopic silicone injection for female stress urinary incontinence due to intrinsic sphincter deficiency: Impact of coexisting urethral mobility on treatment outcome.

Gurdal, M., et al. (2002). Urology, 60, 1016–1019.
Long-term efficacy of submucosal urethral injection for genuine stress incontinence in women.

Zafirakis, H.G., Nathan, S., & Shah, J. (2002).AUA abstract, Florida, USA.
The treatment of sphincter incontinence with periurethral silicone implants (Macroplastique).

Peeker, R., et al. (2002). Scand J Urol Nephrol, 36(3), 194-198.
Transurethral implantation of Macroplastique for the treatment of female stress urinary incontinence secondary to urethral sphincter deficiency.

Radley, S.C., et al. (2001). Eur Urol, 39(4), 383-389.
A single transurethral Macroplastique injection as primary treatment for stress incontinence in women.

Usman, F., et al. (1998). J Obstet Gynaecol, 18(1), 56-60.
Endoscopic correction of intractable stress incontinence with silicone micro-implants.

Sheriff, M.K., et al. (1997). Eur Urol, 32(3), 284-288.
Durability of urethral bulking agent injection for female stress urinary incontinence: 2-year multicenter study results.

Ghoniem, G., et al. (2010). J Urol, 183, 1444-1449.
Effects of Macroplastique Implantation System for stress urinary incontinence and urethral hypermobility in women.

ter Meulen, P.H., et al. (2008). Int. Urogynecol J Pelvic Floor Dysfunct, Epub Oct. 21, 2008.
Macroplastique implantation system for female stress urinary incontinence: Long-term follow-up.

Tamanini, J.T., et al. (2006). J Endourol, 20(12), 1082-1086.
The comparison of artificial urinary sphincter implantation and endourethral Macroplastique injection for the treatment of postprostatectomy incontinence.

Imamoglu, M.A., et al. (2005). Eur Urol, 47(2), 209-213.
The comparison of artificial urinary sphincter implantation and endourethral Macroplastique injection for the treatment of postprostatectomy incontinence.

Imamoglu, M.A., et al. (2005). Eur Urol, 47(2), 209-213.
The treatment of male stress urinary incontinence with polydimethylsiloxane in compliant bladders following spinal cord injury.

Hamid, R., et al. (2003). Spinal Cord, 41, 286-289.
Long term efficacy of Macroplastique injection for the treatment of urinary incontinence in males and females.

Mourad, S. (2003). African J. Urol 2003; 9:80-87
The treatment of male stress incontinence in neuropathic bladders with polydimethylsiloxane.

Arya, M., et al. (2002). Proceedings ICS Annual Meeting, Heidelberg, Germany, August 28-30, 230.
Early results of intraurethral Macroplastique for post radical prostatectomy.

Herschorn, S., & Buencamino, D. (2002). Neurourol & Neurodyn, 21(4), 332.
The treatment of sphincter incontinence with periurethral silicone implants (Macroplastique).

Peeker, R., et al. (2002). Scand J Urol Nephrol, 36(3), 194-198.
Macroplastique injections: How effective is it for stress incontinence in males?

Khastgir, J.N., & Shah, P.J.R. (2000). Proceedings ICS Annual Meeting, Tampere, Finland, August 28-31.
Submucosal bladder neck injections for management of stress urinary incontinence.

Stenzl, A., & Strasser, H. (2000). Brazilian J Urol, 26(20), 199-207.
Intraurethral Macroplastique injections in the treatment of urinary incontinence after prostatic surgery.

Bugel, H., et al. (1999). Prog Urol, 9(6), 1068-1076.
The use of polydimethylsiloxane in the treatment of incontinence after radical prostatectomy.

Colombo, T., et al. (1997). Br J Urol, 80(6), 923-926.
Injectable silicone macroparticles for post-prostatectomy incontinence.

Patterson, P.J., et al. (1993). J Urol, 149(4), S, A86.
Treatment of postoperative male urinary incontinence using transurethral Macroplastique injections.

Kylmälä, T., et al. (2003). J Endourol, 17(2), 113-115.